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The label also carries a boxed warning tied to thyroid C-cell tumor risk observed in rodent studies, and the drug should not be used by anyone with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2
As IAP antagonists induce the degradation of IAP proteins such as cIAP1/2 and can inhibit the activity of XIAP [50], we hypothesised that combination treatment of b-AP15 and IAP antagonists may be synergistic in HNSCC cells
John N Hathcock, Andrew Shao
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