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Additionally, NAC plays a vital role in modulating glutamate, a crucial excitatory neurotransmitter required for normal learning and memory

The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutides 13.7%. Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss. That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary

B., Machado, N

That suggests the issue may not be a class-wide GLP-1 problem, but rather specific to semaglutide drugs