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CagriSema (cagrilintide plus semaglutide) produced 20.4 percent mean weight loss at 68 weeks in the REDEFINE 1 trial, with 60 percent of participants losing at least 20 percent of body weight, approaching bariatric surgery outcomes
The 29 to 31 gauge needle sizes minimize discomfort while remaining adequate for subcutaneous delivery
Criteria for exclusion included weight loss greater than 10% of the group mean, reduced food or water intake, or lack of grooming behavior
Eur J Pharmacol 519(3):277284 Ricciotti E, FitzGerald GA (2011) Prostaglandins and inflammation
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