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Combined with semaglutide as CagriSema, it pushed weight loss to about 22.7% at 68 weeks (REDEFINE-1)
The production of deoxythymidine monophosphate (dTMP) through the reductive methylation of deoxyuridine monophosphate (dUMP) is performed by thymidylate synthase (TS) using the methyl moiety from 5,10-CH2-THF, thereby converting it into dihydrofolate (DHF)
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