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[Diagram suggestion: Three-phase timeline showing bowel movement frequency on Y-axis, weeks on X-axis, with three colored zones representing acute/adaptation/resolution phases and branching paths for resolvers vs persisters] Symptoms that mean constipation vs symptoms that mean obstruction Common constipation symptoms (typical, manageable): Bowel movements less than 3 times per week Hard, pellet-like stools Straining during defecation Sensation of incomplete evacuation Bloating and mild abdominal discomfort Symptoms that suggest something more serious: No bowel movement for 5+ days despite laxative use

Mekonnen, A

First-line mobocertinib versus platinum-based chemotherapy in patients with EGFR Exon 20 insertion-positive metastatic non-small cell lung cancer in the phase III EXCLAIM-2 trial