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They found that a stable GLP-1-estradiol conjugate caused greater weight loss in obese male mice than either GLP-1 controls or labile GLP-1-estradiol conjugates

Compound Reported elimination half-life Source of the figure Tesamorelin (GHRH analog) 8 minutes, single subcutaneous dose in healthy subjects EGRIFTA SV FDA prescribing information Sermorelin (GHRH 1-29) Approximately 11-12 minutes, intravenous or subcutaneous Sermorelin acetate prescribing information Recombinant erythropoietin Roughly 4-13 hours intravenously

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Examples include permanent vision loss, severe gastroparesis requiring feeding tubes, or kidney failure requiring dialysis