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In healthy young adults aged 2040 years, administration of a single dose of carglumic acid 50 mg/kg augmented ureagenesis, as measured by the in vivo synthesis of radiolabeled urea during an intravenous infusion of radiolabeled sodium bicarbonate [2]
The pharmacological reality of peptide degradation in the GI tract makes meaningful oral absorption extremely unlikely without specialized encapsulation technology (which is still largely experimental for peptides of this size)
And that's one of the big limitations of the stool studies
GLP-1 receptor agonists promote weight loss by suppressing appetite, enhancing satiety (the feeling of fullness), and delaying gastric emptying
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