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To mitigate reverse causality effects, the observation period was initiated the day following the index date and continued for a maximum duration of 5 years

Spironolactone also has partial progesterone-receptor agonist activity, and progesterone itself has sedating, anxiolytic properties that can improve sleep onset and increase slow-wave sleep in premenopausal women

Diversas investigaciones han constatado que las mujeres continan experimentando una presin esttica significativamente mayor que los hombres