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Future Directions and Challenges 1

The efficacy of this therapeutic combination was first validated in our breast cancer models, demonstrating that PHGDH wild type breast cancer cells do not respond to the therapeutic combination, whereas PHGDH-amplified breast cancer cells exhibited a synergistic sensitivity to suboptimal dosages of sertraline plus chloroquine (Figure S8A)

Synedica BPC 157 & TB 500 40mg Pen is a research-grade peptide combination formulation examined for regenerative pathway interaction and cellular signalling behaviour in controlled laboratory settings