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Of particular note are a randomised, placebo-controlled trial enrolling participants with impaired glucose tolerance [108], testing metformin up to 1 g twice daily versus placebo for 2 years, and a trial (MET-PREVENT) [109] enrolling older people with probable sarcopenia, testing metformin 500 mg three times a day versus placebo for 4 months

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Some preliminary research suggests that GLP-1 receptor agonists might have anti-inflammatory properties and could potentially influence gut microbiome composition, but these findings remain investigational and have not translated into clinical practice or FDA-approved indications

Gut microbiota can also produce bioactive metabolic substances that enter the blood circulation, and then affect the bodys metabolic process (Wang Y