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The D-Retro-Inverso modification (using D-amino acids in reverse sequence) provides resistance to proteolytic degradation while maintaining the ability to interfere with the target protein interaction
Folate deficiency leads to the accumulation of homocysteine which is associated with an increased risk of cerebrovascular diseases, depression, and dementia, with a focus on vascular dementia and Alzheimers disease (4, 20, 22)
10.2174/1567205019666220318092003 Curr Alzheimer Res
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