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It is important to note that depression is not listed as a common or established side effect in the official Summary of Product Characteristics (SmPC) for Rybelsus, nor in guidance from the MHRA or European Medicines Agency (EMA)
Duration varies per individual
10.1038/s41401-021-00726-0 28 LiY.de HaarC.ChenM.DeuringJ.GerritsM
Using the Ala 28 from GIP may decrease affinity with GLP-1R and increase the activities of the two receptors in vitro, but it is likely to decrease these activities in vivo
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