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Because SAM is also required for many other methylation reactions, including gene-expression regulation, high NNMT activity draws heavily on SAM and is associated in studies with reduced NAD, a coenzyme central to cellular energy production
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Funding This work was supported by funding from the Sanming Project of Medicine in Shenzhen (SZSM201612051), the opening project of State Key Laboratory of Explosion Science and Technology (Beijing Institute of Technology, KFJJ22-16M), National Nature Science Foundation of China (81970467), and CAMS Innovation Fund for Medical Sciences (CIFMS, 2019-I2M-1-003)
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