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Science 356 , eaam7263 (2017)
The leached amount would be attributed to the poor association/adsorption of a small fraction of the AuNCs with/at the surface of PLGA in resemblance to the known burst release of encapsulated drugs in PLGA nanohosts
They report that transcript abundance changed, which is not the same claim as that a function changed, and the gap between those two statements is where most over-reading of this compound happens
Some clinical studies and recent reviews suggest that oral glutathione may contribute to brightening or melasma-related improvement in certain contexts, often around the 250 to 500 mg per day range, but the body of evidence is still relatively small and not as robust as the marketing often implies
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