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on the other hand, the restored autophagy system accelerates the clearance of damaged mitochondria (mitophagy), blocks the continuous generation of ROS, thereby downregulating the Bax/Bcl-2 ratio and inhibiting Caspase-3/7 activity, ultimately significantly reducing the apoptosis level of renal tubular epithelial cells
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Moreover, micro-CT and histological analysis demonstrated that metformin could moderately delay the progression of OA as well
In this regard, Chonluten might play a role in modulating intracellular responses to reactive molecular species, potentially influencing how cells adapt to fluctuating conditions
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