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The review contextualised native GLP-1 as the reference molecule for the entire dual GIP/GLP-1 receptor agonist research field including tirzepatide (approved) and novel triple agonists targeting GLP-1R, GIPR, and GCGR simultaneously confirming native GLP-1s ongoing research importance as the pharmacological anchor of this rapidly expanding compound class

Reaching a higher research figure typically depends on confirmed tolerance at earlier, lower levels first

But the shortages and challenges with insurance coverage have made it difficult for many patients to get the drugs

Express Scripts and eviCore are financially incentivized to make patients try the cheaper option first, regardless of comparative efficacy