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Our results agree with previous data showing that TIR significantly activated PI3K/AKT/GSK3 signaling pathway ameliorating insulin resistance in the hippocampus of diabetic rats [25]
1) lead to an unparalleled impact on cardio-metabolic pathways by reducing food intake and related reward, increasing satiety, decreasing inflammation and atherogenesis, improving glucose metabolism and storage as well as cardiac, vascular, muscle and adipose tissue function
As a synthetic peptide and dual receptor agonist, tirzepatide is studied for its effects on appetite regulation, glucose metabolism, metabolic pathways, and energy expenditure
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