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3 COMT inhibitors, such as entacapone, opicapone, and tolcapone, and MAO-B inhibitors, such as selegiline, rasagiline, and safinamide, work by enhancing levodopas duration of action with inhibition of their respective enzymes
S.BoutronI.et al (2019)
The starting dose is just the first step
how- ever, there is still much to be learned regarding the neuronal sites of action that underlie its suppressive effects on food intake and body weight
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