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For semaglutide, treatment was initiated at 0.25 mg once weekly and titrated every 4 weeks (0.25 mg 0.5 mg 1.0 mg) until the approved maintenance dose of 1.0 mg was achieved
Melena is black, tarry stool from digested blood, often linked with upper digestive bleeding
A 2025 systematic review of four randomized controlled trials involving 27,617 participants showed that semaglutide reduces MACE by 19% (relative risk 0.81, 95% CI 0.74-0.88), with additional benefits for cardiovascular death and nonfatal heart attack
Clinical efficacy and safety of sodium-glucose cotransporter protein-2 (SGLT-2) inhibitor, glucagon-like peptide-1 (GLP-1) receptor agonist, and Finerenone in type 2 diabetes mellitus with non-dialysis chronic kidney disease: a network meta-analysis of randomized clinical trials
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