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For mild to moderate joint discomfort without red flag features, management should be guided by NICE NG226 (Osteoarthritis in over 16s: diagnosis and management) and may include: Exercise and physiotherapy , which are central to NICE-recommended management
W., Chang, W
These effects were dose-dependent, emerging only at 50 mg/kg/daya level still classified as safe in animals by regulatory standards
Documented protocols describe starting at 20 mcg for the first 2-3 days to assess tolerance, then increasing to 50 mcg if well-tolerated
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