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In cases where an employer is providing plan coverage for GLP-1 medications for obesity, there are risks and potential unforeseen consequences if the coverage doesnt have a defined plan structure and a managed process for treatment
Investigators have also noted that the pronounced appetite-stimulating effect of MK-677 an on-target consequence of ghrelin receptor agonism in hypothalamic appetite circuits complicates body composition endpoints in metabolic studies, as caloric intake must be carefully controlled to isolate GH-axis-mediated changes from orexigenic-driven weight gain
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