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Bibcode:1993NYASA.680..279B
GLP-1 Longevity of Use The timeline of GLP-1 usage is distinctly different based on the drugs use case
They share the same cyclic scaffold and differ at the C-terminus: Melanotan II is amidated (-NH) while PT-141 carries a free acid (-OH)
The most common reasons include: Gastrointestinal side effects such as nausea, vomiting and diarrhea which are the single most frequently documented reason for stopping in large health system datasets High out of pocket cost and lack of insurance coverage particularly in individuals without diabetes Medication unavailability or pharmacy supply shortages which peaked in 2023early 2024 Perceived completion of therapy once target weight is reached or weight loss plateaus Concerns about long term safety or treatment burden of injections Many cohorts show substantial discontinuation by 3 months, with further losses by 6-9 months
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