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Semaglutide intervention affects the biosynthesis of phenylalanine, tyrosine, and tryptophan, phenylalanine metabolism, arginine biosynthesis, as well as arginine and proline metabolism in obese mice

2,3 All of these factors metabolic improvements, restoration of ovulation, more predictable cycles, and potential interactions with oral contraceptives may help explain why unplanned pregnancies are occurring among people using GLP-1s

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SURPASS evaluated glycemic control and metabolic outcomes in adults with type 2 diabetes