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Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction
GLP-1 medications suppress appetite, which often leads to significant reductions in calorie intake, protein intake, and hydration
About Alexis Day Alexis Day has a Doctor of Pharmacy (PharmD) degree with over 15 years of experience as a clinical pharmacist
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