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Nature PubMed Preclinical literature and narrative reviews describe pleiotropic actions including angiogenesis modulation (promotion in healing contexts and proposed inhibition in rodent corneal neovascularization models) and purported cytoprotective effects across diverse injury paradigms, but these remain unconfirmed in controlled human experiments
The plates were briefly stirred and activity was monitored at 418 nm in kinetic mode using a plate reader SpectraMax ABS Plus (Molecular Devices)
Human studies show that I3C pushes more estrogen toward the favorable 2-hydroxyestrone route (the less active one) and reduces the amount going down the more estrogenically active 16-hydroxyestrone pathway [7, 8]
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