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Theranostics (2020) 10(12):541234
It plays a central role in the livers phase II detoxification pathways, conjugating with heavy metals such as mercury and cadmium to facilitate their safe elimination from the body [1]
At the catabolic level, they directly inhibit the myoprotein degradation process mediated by the ubiquitin-proteasome pathway by downregulating the expression of two core E3 ubiquitin ligases, atrogin-1 and MuRF-1
Its an exciting example of how metabolism and neuroscience intersect the gut-brain axis in action
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