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If glucagon agonism added to GLP-1 agonism could deliver the incretin's appetite suppression and glycemic control while simultaneously driving the thermogenic, hepatic, and energy-expenditure benefits the antagonist programs had been inadvertently shutting off, the combination might outperform either lever alone
PMID: 42 XuXLinLChenPYuYChenSChenXet al
Understanding these possible reasons for irritability can help patients and doctors find ways to manage it
Research following patients for two years found no major safety concerns
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