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doi: 10.21037/atm.2020.02.172 98 LiuWJShenTTChenRHWuHLWangYJDengJKet al

M.GomesA

A 2014 pharmacokinetic study demonstrated that ketoconazole (a strong CYP3A4/P-gp inhibitor) increased apixaban AUC by approximately 100%, while rifampin (a strong inducer) decreased it by roughly 54% [1]