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The chronic depletion of GSH, closely linked to ageing and diabetes, can precipitate cell death and impede cell division in the RPE via the mechanisms described above [18,19]

For individuals considering glutathione or other skin interventions, understanding your genetic predispositions in antioxidant and melanin regulation pathways may provide context for realistic expectations and more informed conversations with dermatologists about safety and efficacy

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Linus Pauling Institute Oregon State University Updated in November 2004 by: Jane Higdon, Ph.D