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Research Evidence Comparison# Survodutide Research# Survodutide's clinical evidence is growing but remains primarily Phase 2: Phase 2 obesity trial : Randomized, dose-ranging study demonstrated up to 18.7% body weight loss at 46 weeks with the 4.8 mg dose, with dose-dependent efficacy across all arms Phase 2 MASH trial : Demonstrated significant reductions in liver fat content measured by MRI-PDFF, with histological improvement in MASH activity scores including inflammation and ballooning

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In 2016 Topol was awarded a $207 million grant from the National Institutes of Health to lead a significant part of the Precision Medicine Initiative (All of Us Research Program), a one-million-American prospective research program

In both cases, there are important compliance and PBM contractual considerations that need to be explored and fully vetted as part of decision making