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Transcription-Factor Pathway Analysis: Suitable for molecular experiments examining FOXO transcription factor signaling and gene regulation

Exogenous Causes UV Exposure Prolonged exposure to ultraviolet (UV) rays can damage hair and skin cells, including the melanocytes, contributing to premature greying

The metabolites cyclic 3-hydroxy melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), which can reduce free radicals, are formed when MLT reacts directly with free radicals, including hydroxyl (OH ), superoxide (O 2 ), and reactive nitrogen species, such as nitric oxide (NO ) The hypothesis that MLT has a multifunctional role as a mitochondrial antioxidant is supported by numerous investigations [116,117,118]