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LAURIE SUND: First of all, just letting you know I'm really passionate about this, because obesity is the second leading cause of preventable illness and death, and 42% of our population has obesity
Furthermore, concentrations of up to 300 mM glucose do not induce GLP-1 secretion from colonic human mucosa because GLP-1 producing L-cells barely express SGLT1 (43, 53, 58, 72)
Requires short-horizon biomarker readouts (ApoB, hsCRP, CGM variability, MRI-PDFF, FMD) and robust outcomes trials to validate
In past 1 month, have you been treated with one of the following: Upadacitinib or Rinvoq
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