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Lysosomal hydrolases are synthesized in the endoplasmic reticulum (ER), modified in the Golgi apparatus with mannose 6-phosphate tags, and recognized by mannose 6-P receptor (MPR)

Superior weight loss: The combination consistently achieves ~2023% weight reduction, outperforming either drug alone and placing it among the strongest results in the obesity pharmacotherapy landscape (Reuters

Recent reports have found that GPX4 deletion induces iron apoptosis in M2, while M1 does not, largely because iNOS is a negative regulator of iron apoptosis and promotes M1 survival (148)

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