non glp 1 Each generation of GLP-1 agonist is harder to test than the last. Semaglutide has one non-natural amino acid and a C-18 fatty acid at one attachment point. Tirzepatide has two non-natural amino Metabolic Axis Peptidyl and Non-Peptidyl Oral Glucagon-Like
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![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)





