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397,398 The KAITLIN phase 3 study compared anthracycline-based chemotherapy and then 18 cycles of T-DM1 plus pertuzumab (AC-KP) to taxane (threefour cycles) plus trastuzumab plus pertuzumab (AC-THP), adjuvant AC-KP did not result in statistically significant or clinically meaningful improvement in iDFS compared with AC-THP in patients with high-risk early breast cancer