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Although originally described as an ATP-dependent enzyme, recent work has demonstrated that TPK1 can utilize several nucleotides as phosphate donors for the phosphorylation of thiamine
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[124] Other causes of B 12 malabsorption include bariatric surgery, pancreatic insufficiency, obstructive jaundice, tropical sprue, celiac disease, inherited intrinsic factor deficiency, and radiation enteritis affecting the distal ileum
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