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Most studies have investigated the isolated compound silymarin or its most active isomer silybin, rather than the plant part in its whole form
In addition, the presence of denatured biological molecules and macromolecules can cause a range of undesired biological responses
Unlike normal astrocytes, which suppress cholesterol production under conditions such as high cell density, GBM cells frequently have sustained activation of the cholesterol biosynthetic pathway (69)
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