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Interestingly, BSO significantly enhanced L-PAM-induced apoptosis in TP53 -mutated MM cell lines, suggesting that BSO+L-PAM can achieve p53-independent cell death as described previously
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To compensate for this sudden loss of blood pressure, the autonomic nervous system triggers severe tachycardia (a rapid heart rate), manifesting as Postural Orthostatic Tachycardia Syndrome (POTS) and other forms of dysautonomia
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