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The superior metabolic benefits observed with concomitantly targeting GLP-1 and GIP receptors garnered interest in developing unimolecular drugs that would combine the actions of GLP-1 and GIP (Figure 1)
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Research is mixed, but a 2025 systematic review reported that microbiome interventions (e.g., probiotics) generally improved body weight, body fat percentage, and metabolic parameters (e.g., lipid levels, glucose metabolism) in people with obesity
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