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after reaching this dose, patients should be directed by their doctor to increase the dose monthly as tolerated to no more than the maximum dose
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This is mediated by inhibition of phosphorylation of PDGFR, FGFR1, FGFR2, VEGFR2, and several Src family kinases including Src, Lck, Lyn as well as activation of STAT3, NF-B, and Smad-3 in the kidney
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