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Although the underlying contributors to these differences cannot be determined from observational data, potential factors may include variation in baseline clinical characteristics, access to care, treatment persistence, dose escalation, social determinants of health, and unmeasured biological heterogeneity
The outcome depends on which eye problem develops and how quickly it receives treatment
Current data shows tirzepatide produces slightly more total weight loss (20.9% vs 14.9-18.7%), but the trials used different durations
