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Acknowledgements This material is the result of work supported with resources and the use of facilities at the Orlando VA Healthcare System (Orlando, Florida)

Pharmacokinetic Parameters Clinical Uses Glycemic control in type 2 diabetes Chronic weight management in obesity and overweight (with risk comorbidities) Adverse Effects Gastrointestinal: nausea, vomiting, diarrhea, constipation Risk of pancreatitis (rare) Possible gallbladder disease (e.g., cholelithiasis) Mild injection-site reactions Contraindicated in individuals with personal or family history of medullary thyroid carcinoma or MEN2 Comparative Analysis MCQs Semaglutide activates which receptor

Targeting the p53-FOXO4 Axis: In senescent cells, the protein FOXO4 binds to p53 and sequesters it in the nucleus, preventing p53 from triggering cell death