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Furthermore, LBP can activate anti-apoptotic signaling pathways in retinal cells, including phosphatidylinositol 3-kinase (PI3K)/protein kinase (Akt)/mammalian target of rapamycin (mTOR), enhance cell survival factor expression, and inhibit the activation of apoptosis-related proteins, directly combating the process of cell apoptosis (Qi et al., 2022)

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For those wondering about the differences between semaglutide, tirzepatide, and retatrutide , the data shows a clear hierarchy of efficacy forming among incretin-based therapies