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The synchrotron radiation experiments were performed at the BL41XU of Spring-8 with approval of the Japan Synchrotron Radiation Research Institute (JASRI) (proposal no
GLP-1 and the hypothalamus: GLP-1 acts in the brain to reduce appetite, and animal research hints it might also influence GnRH neurons or other neuroendocrine pathways
Researchers compared women who took the drug alongside hormone therapy with women who took just the GLP-1 and found that women who took both lost more weight than those just taking the weight loss drug alone
However, drugs that block other receptors, such as alpha-2 adrenoceptors, dopamine D2 and D3 receptors, and serotonin 5-HT2A/C receptors, had no significant effect on tesofensines appetite-suppressing action
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