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Therapeutic modulation of autophagy in cardiovascular disease Autophagy has emerged as one of the most actively investigated proteostasis pathways for therapeutic intervention in cardiovascular disease

To evaluate the ability of molecules to interfere with aggregation of hCC while informing about cellular toxicity, cells were generated that produce and secrete WT and L68Q-hCC producing high-molecular weight complexes formed from the mutant protein

Kim et al., 2011), ULK1-associated ATG13 (Jung et al., 2009), and ATG14 (Yuan et al., 2013), which disrupts autophagy induction and autophagosome nucleation and maturation

USA 107 , 85878592 (2010)