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Conclusions The findings of this meta-analysis of seven RCTs (6609 participants) suggest a dose-dependent superiority of all three tirzepatide maintenance doses on glycaemic control, not only vs placebo but also vs long-acting GLP-1 RAs and basal insulin regimens

Contact your GP or diabetes care team if you experience: Vomiting that persists for more than 24-48 hours Inability to keep down fluids, leading to signs of dehydration (dark urine, dizziness, dry mouth, reduced urination) Vomiting accompanied by abdominal pain Blood in vomit or vomit that resembles coffee grounds Significant unintentional weight loss beyond expected therapeutic effects Symptoms of hypoglycaemia (low blood sugar) that you cannot manage, particularly if you are also taking insulin or sulfonylureas Seek urgent medical attention (A&E, NHS 111, or call 999) if you develop: Severe, persistent abdominal pain with vomiting, particularly if the pain is constant and located in the upper abdomen radiating to the backthis could indicate pancreatitis

Engineered regulatory T cells (Tregs) Adaptive Treg therapy involves isolating patient Tregs, expanding them outside the body (ex vivo), and potentially enhancing their function or antigen specificity through genetic modification prior to reintroduction