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B12 is available in oral supplements, but it is recommended to get the shots because they are more effective than pills
A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines
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Animal studies and a very small uncontrolled human pilot study exist
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