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Ryskjaer, J
Even though the 3D structure of OCTN2 is still not known, the molecular determinants for substrate specificity have been revealed: one ammonium and one carboxylate groups are strictly required for transport, while the distance between them is not important (Ohashi et al., 2002
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Glutathione participates in phase II detoxification by GST-mediated conjugation of electrophiles such as drugs, heavy metals, and lipid peroxides forming mercapturates that are eliminated via MRP/ABCC transporters
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