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1 Pathophysiology The disease is almost universally driven by somatic JAK2 mutations that confer cytokine-independent signaling: JAK2 V617F occurs in ~95% of PV, and JAK2 exon 12 mutations account for most of the remainder

But notably those with obesity had a slightly lower prevalence rate ratio, so maybe less alcohol use as compared to those without obesity. There are some limitations of the analysis, she acknowledged, pointing to the cross-sectional design and the possibility of unmeasured confounding

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Yesif you reach your weight loss goal at 1.0 mg or 1.7 mg, continuing to escalate serves no purpose and only increases side effect risk