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Autophagy-related proteins ATG4 and ATG7, important for autophagosome formation, are regulated by Trx (138,139)
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For example, ipamorelin increases GH secretion with minimal effect on cortisol or prolactin, which is not always the case with other peptides
Due to this added complexity, orthogonal methods are required to characterize the critical quality attributes. This popularity has come with significant caveats
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